The Association between Thrombin Antithrombin Complex and Foetal Outcomes in Women with Preeclampsia-Eclampsia at the University of Benin Teaching Hospital, Benin City, Nigeria
Preeclampsia and eclampsia are major contributors to perinatal morbidity and mortality globally. Haematologic derangements have been associated with adverse perinatal outcomes in women with preeclampsia. However, this has not been adequately investigated in our environment. This study aimed at determining the association between thrombin antithrombin complex (TAT) and foetal outcomes in patients with Preeclampsia-eclampsia. This is a hospital-based cross-sectional study conducted at the university of Benin teaching hospital, Benin City, Edo state. Seventy-two preeclampsia-eclampsia women and seventy controls participated in the study. Full blood count parameters were estimated using an auto analyser (Sysmex Haematology Autoanalyser model KN21). Thrombin antithrombin complex was estimated using the enzyme-linked immunosorbent assay method. Data were analyzed using the statistical package for social sciences (SPSS) version 21. The mean TAT concentration for women with preeclampsia-eclampsia was significantly higher than the control group (19.6 ± 3.2µg/L vs 15.7 ± 3.9µg/L; p = < 0.001). Newborns born of women with preeclampsia-eclampsia had low birth weight in comparison with controls (33.3% vs 4.3%; p = < 0.001). Babies born in the study group also had more neonatal intensive care unit (NICU) admissions and foetal death than in the normotensive group (45.8% and 33.3% vs 5.7% and 1.4% respectively). Preeclampsia-eclampsia is associated with elevated TAT levels in women with preeclampsia- eclampsia and there was a significant association with foetal low birth weight, admission into NICU and perinatal mortality.