Ethanolic Extract of Musa Sapientum Banana Spotted Peel Treatment Better Ameliorates Ccl Induced Nephrotoxicity Than Green or Yellow Peels in Male 4 Wistar Rats

Turning waste to value is trending issue of global importance, and Musa sapientum (Banana) peels are mostly discarded as waste, however spotted peels have been reported to possess rich antioxidants; this study investigated ethanolic extracts of Musa sapientum green, yellow and spotted peels treatment on the kidney histology and renal function parameters following carbontetrachloride (CCl ) exposure in male Wistar rats. 50 4 rats (180 - 220g) divided into 10 groups (I - X) of 5 rats per group: Groups I (normal control), Groups (II, IV, V, VI, VII, VIII, IX and X) was injected with CCl intraperitoneally. III (vehicle) received 10% of tween 80 and 4 olive oil. IV and V received 500 and 1000 mg/kg body weight yellow peels extract, VI and VII received 500 and 1000 mg/kg body weight green peels extract, VIII and IX were administered 500 and 1000 mg/kg body weight spotted peels extract, while X received vitamin C 300 mg/kg body weight. Administration was for 21 days. Results showed significant (p<0.05) increase in creatinine and urea concentrations in CCl -exposed group 4

• compared with control and treated groups, also there were significant (p<0.05) increase in K concentration in CCl -induced group and in groups that received the different peels ethanolic extract at 1000 mg/kg when 4 compared with control. Histology revealed severe distortions in renal tubes, glomerulus and occlusion of urinary space in CCl -exposed group compared to control and treated groups. However there were marked 4 nephro-protection in groups IX and X. In conclusion, ethanolic extract spotted peels of Musa sapientum through its antioxidants activity better ameliorates against CCl -induced nephrotoxicity in a dose-dependent 4 concentration than the green and yellow peels.