Stem Bark Extract of Cinnamomum Zeylanicum (Cinnamon) Could Serve a Protective Role on Opioids Induced Toxicity on Male Fertility using Sprague Dawley Model of Rat

Cinnamon is a natural herb that has a long history of safety and has so many health benefits. Fertility is the natural capacity to conceive a child. The issue of infertility affects both sexes equally. This study was therefore aimed at evaluating the potential of cinnamon to protect against opioid-induced toxicity in the male Sprague-Dawley rat model. A total of 30 rats were used in this study. The rats were weighed and divided into three groups. Group A (Control) received only normal feed (growers’ mash) and distilled water, Group B received tramadol, rohypnol, and codeine, Group C received tramadol, rohypnol, and codeine and Cocosnucifera extract for 42 days (6 weeks). The animals were weighed, euthanized, and sacrificed, after which the serum was collected for testosterone evaluation and testicular tissue for histological processing. A highly significant reduction was seen in groups B, and degeneration was seen in the testes; however, improvement was seen in group C. The cell alterations caused by these substances could be alleviated using Cinnamomum zeylanicum.